Uniform Surface Modification of 3D Bioglass(®)-Based Scaffolds with Mesoporous Silica Particles (MCM-41) for Enhancing Drug Delivery Capability

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Boccardi E, Philippart A, Juhasz-Bortuzzo J, Beltrán AM, Novajra G, Vitale-Brovarone C, Spiecker E, Boccaccini AR
Zeitschrift: Frontiers in Bioengineering and Biotechnology
Jahr der Veröffentlichung: 2015
Band: 3
ISSN: 2296-4185
Sprache: Englisch


Abstract


The design and characterization of a new family of multifunctional scaffolds based on bioactive glass (BG) of 45S5 composition for bone tissue engineering and drug delivery applications are presented. These BG-based scaffolds are developed via a replication method of polyurethane packaging foam. In order to increase the therapeutic functionality, the scaffolds were coated with mesoporous silica particles (MCM-41), which act as an in situ drug delivery system. These sub-micron spheres are characterized by large surface area and pore volume with a narrow pore diameter distribution. The solution used for the synthesis of the silica mesoporous particles was designed to obtain a high-ordered mesoporous structure and spherical shape – both are key factors for achieving the desired controlled drug release. The MCM-41 particles were synthesized directly inside the BG-based scaffolds, and the drug-release capability of this combined system was evaluated. Moreover, the effect of MCM-41 particle coating on the bioactivity of the BG-based scaffolds was assessed. The results indicate that it is possible to obtain a multifunctional scaffold system characterized by high and interconnected porosity, high bioactivity, and sustained drug delivery capability.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Boccardi, Elena
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Philippart, Anahi
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Spiecker, Erdmann Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung)


Zusätzliche Organisationseinheit(en)
Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung)
Interdisziplinäres Zentrum, Center for Nanoanalysis and Electron Microscopy (CENEM)


Einrichtungen weiterer Autorinnen und Autoren

Politecnico di Torino


Zitierweisen

APA:
Boccardi, E., Philippart, A., Juhasz-Bortuzzo, J., Beltrán, A.M., Novajra, G., Vitale-Brovarone, C.,... Boccaccini, A.R. (2015). Uniform Surface Modification of 3D Bioglass(®)-Based Scaffolds with Mesoporous Silica Particles (MCM-41) for Enhancing Drug Delivery Capability. Frontiers in Bioengineering and Biotechnology, 3. https://dx.doi.org/10.3389/fbioe.2015.00177

MLA:
Boccardi, Elena, et al. "Uniform Surface Modification of 3D Bioglass(®)-Based Scaffolds with Mesoporous Silica Particles (MCM-41) for Enhancing Drug Delivery Capability." Frontiers in Bioengineering and Biotechnology 3 (2015).

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Zuletzt aktualisiert 2019-29-05 um 15:24