Pomegranate (Punica granatum L,) wine polyphenols affect Nrf2 activation and antioxidant enzyme expression in human neuroblastoma cells (SH-SY5Y)

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autor(en): Li X, Liu L, Pischetsrieder M
Zeitschrift: Journal of Functional Foods
Jahr der Veröffentlichung: 2017
Band: 38
Seitenbereich: 140-150
ISSN: 1756-4646
Sprache: Englisch


Abstract


Pomegranate (Punica granatum L.) phenolic compounds may prevent oxidative stress-induced neurodegenerative diseases. The present study investigated cytoprotective effects of pomegranate wine extracts and their phenolic compounds in neuroblastoma cells SH-SY5Y. The extracts significantly activated nuclear factor erythroid 2-related factor 2 (Nrf2; ≤2.6-fold) and inhibited nuclear factor κB (NF-κB) nuclear translocation (≥26% activity) without cytotoxic effects. Moreover, pomegranate wine extract time-dependently elevated heme oxygenase-1 (HO-1) expression (≤2.9-fold) and promoted superoxide dismutase (SOD) activity (≤1.4-fold), while it had no significant effect on glutathione peroxidase (GPx) activity. The main phenolic components of the extracts, gallic acid, ellagic acid, and punicalagin also led to a significant inhibition of NF-κB and the activation of Nrf2 translocation and subsequent increase of HO-1 expression and SOD activity, dependent on concentration and incubation time. Thus, pomegranate wine and its phenolic components may have a protective effect on neuronal cells by triggering Nrf2 and inhibiting NF-κB signaling.



FAU-Autoren / FAU-Herausgeber

Li, Xuan
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Pischetsrieder, Monika Prof. Dr.
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)


Zitierweisen

APA:
Li, X., Liu, L., & Pischetsrieder, M. (2017). Pomegranate (Punica granatum L,) wine polyphenols affect Nrf2 activation and antioxidant enzyme expression in human neuroblastoma cells (SH-SY5Y). Journal of Functional Foods, 38, 140-150. https://dx.doi.org/10.1016/j.jff.2017.08.048

MLA:
Li, Xuan, Linwei Liu, and Monika Pischetsrieder. "Pomegranate (Punica granatum L,) wine polyphenols affect Nrf2 activation and antioxidant enzyme expression in human neuroblastoma cells (SH-SY5Y)." Journal of Functional Foods 38 (2017): 140-150.

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Zuletzt aktualisiert 2018-10-08 um 21:40