Modulation of host cell apoptotic pathways by intracellular pathogens

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Friedrich A, Pechstein J, Berens C, Lührmann A
Zeitschrift: Current Opinion in Microbiology
Jahr der Veröffentlichung: 2017
Band: 35
Seitenbereich: 88-99
ISSN: 1369-5274


Abstract


Nearly all steps of the host cell apoptotic cascade can be subverted by intracellular microorganisms. Some pathogens modulate early steps and interfere with sensing of extracellular signals, cellular stress or signal transduction; others target Bcl-2 proteins, caspases, or inhibitor of apoptosis proteins (IAPs). In many cases the exact molecular mechanisms leading to interference with the host cell apoptotic cascade are still unknown. However, there are some examples where bacterial factors that modulate host cell death have been identified. In this review we will summarize recent findings on how intracellular pathogens or their secreted proteins alter the intrinsic and/or extrinsic host cell apoptotic pathways.



FAU-Autoren / FAU-Herausgeber

Friedrich, Anja
Sonderforschungsbereich 796 (mit integriertem Graduiertenkolleg) Steuerungsmechanismen mikrobieller Effektoren in Wirtszellen
Pechstein, Julian
Professur für Mikrobiologie


Autor(en) der externen Einrichtung(en)
Friedrich-Loeffler-Institut (FLI), Bundesforschungsinstitut für Tiergesundheit


Zitierweisen

APA:
Friedrich, A., Pechstein, J., Berens, C., & Lührmann, A. (2017). Modulation of host cell apoptotic pathways by intracellular pathogens. Current Opinion in Microbiology, 35, 88-99. https://dx.doi.org/10.1016/j.mib.2017.03.001

MLA:
Friedrich, Anja, et al. "Modulation of host cell apoptotic pathways by intracellular pathogens." Current Opinion in Microbiology 35 (2017): 88-99.

BibTeX: 

Zuletzt aktualisiert 2018-05-10 um 02:15