Modulation of host cell apoptotic pathways by intracellular pathogens

Friedrich A, Pechstein J, Berens C, Lührmann A (2017)


Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 35

Pages Range: 88-99

DOI: 10.1016/j.mib.2017.03.001

Abstract

Nearly all steps of the host cell apoptotic cascade can be subverted by intracellular microorganisms. Some pathogens modulate early steps and interfere with sensing of extracellular signals, cellular stress or signal transduction; others target Bcl-2 proteins, caspases, or inhibitor of apoptosis proteins (IAPs). In many cases the exact molecular mechanisms leading to interference with the host cell apoptotic cascade are still unknown. However, there are some examples where bacterial factors that modulate host cell death have been identified. In this review we will summarize recent findings on how intracellular pathogens or their secreted proteins alter the intrinsic and/or extrinsic host cell apoptotic pathways.

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How to cite

APA:

Friedrich, A., Pechstein, J., Berens, C., & Lührmann, A. (2017). Modulation of host cell apoptotic pathways by intracellular pathogens. Current Opinion in Microbiology, 35, 88-99. https://dx.doi.org/10.1016/j.mib.2017.03.001

MLA:

Friedrich, Anja, et al. "Modulation of host cell apoptotic pathways by intracellular pathogens." Current Opinion in Microbiology 35 (2017): 88-99.

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