P153: Dysregulated compartment-specific neuronal transcriptome through alternative splicing in ALS
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.04.2024
End date : 31.03.2025
Project details
Scientific Abstract
The etiology of ALS, a fatal neurodegenerative disease, remains unclear. Our research focuses on the 'dying-back' mechanism, where neuron degeneration starts from synapses/axons. We aim to study if faulty mRNA splicing causes RNA mislocalization in axons and synapses, potentially exacerbating this mechanism by making use of iPSC-derived motor neurons from ALS apteints andd APEX2 RNA-proximity labeling in neuronal compartments.
Involved:
Contributing FAU Organisations:
Professur für Stammzell-Modelle seltener neuraler Erkrankungen
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
