P044: The role of HIF-1a mediated glycolysis in IgA class switching during bacterial infection
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.08.2019
End date : 15.08.2020
Project details
Scientific Abstract
Germinal center (GC) has been described to contain hypoxic regions linked to B cell class switching. In this project, we will delineate molecular mechanism between HIF-1a-dependent glycolysis and epigenetic modification on IgA class switching region. By studying the IgA response following the C. rodentium infection, we aim to identify the link between the HIF-1a-dependent glycolytic metabolic shift and IgA class switching during microbial infection.
