P119: Analysis of intestinal tryptophan metabolites as factors in inflammation and extraintestinal manifestations
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.08.2023
End date : 31.07.2024
Project details
Scientific Abstract
Extraintestinal manifestations (EIM) are frequent in IBD patients. Our initial data revealed an osteoporosis-& PSC-like phenotype in a murine IBD model. Intestinal inflammation was linked to altered tryptophan metabolism and AHR-signalling, which are assumed to be mediators of EIM. While previous data demonstrate an impact on this pathway, mechanistic knowledge is limited. Within this project we will take advantage of 3D organ cultures to better understand the tryptophan-AHR axis in IBD and EIM.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Medizinische Fakultät
