P121: Targeting aggNETs for resolution of inflammation on the ocular surface
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2023
End date : 30.06.2024
Project details
Scientific Abstract
Eye rheum is a physiological ocular surface discharge contains aggregated neutrophil extracellular traps (aggNETs), indicating that neutrophils are involved in ocular surface homeostasis. In the murine model of allergic eye disease, aggNETs occlude meibomian glands causing meibomian gland dysfunction after ocular surface inflammation. Here we plan to investigate therapeutic potential of eye drops containing DNase-1 or NOX2-inhibitor to alleviate aggNETs driven ocular surface inflammation.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
