P118: GPR179 and LRRTM4: two new players in night vision accociated with GABA receptors
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2023
End date : 01.02.2024
Extension date: 31.07.2024
Project details
Scientific Abstract
We will analyse two new players of the rod pathway in the mammalian retina that are associated with night blindness - GPR179 and LRRTM4. GPR179 and LRRTM4 bind directly to GABAc receptors (GABAcR). Rod bipolar cells express high levels of GABAcR and deletion of LRRTM4 perturbed clustering of GABAcR at their axon terminals. We will analyse these protein complexes in the retina, map binding sites and elucidate functions of the interactions by cell biology, calcium imaging and electrophysiology.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Professur für Biochemie und Medizinische Molekularbiologie
Medizinische Fakultät
