P071: Induction of tissue-resident memory T cells against lung cancer
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2021
End date : 31.01.2022
Project details
Scientific Abstract
Lung cancer is the most prevalent and deadly type of cancer. Although immunotherapy with checkpoint inhibitors can improve the clinical outcome, only a minority of patients responds to this treatment. Recent studies suggest that tissue-resident memory T cells (TRM) in the tumour mass correlate positively with prognosis and are essential for efficacy of immunotherapy. In the present study, a novel mucosal vaccination strategy will be employed to induce lung TRM against defined tumour antigens.
Involved:
Contributing FAU Organisations:
Institute of Clinical and Molecular Virology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
