P056: Using self-renewing liver organoids to understand hepatobiliary organogenesis and host-microbial interaction
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.04.2020
End date : 31.03.2021
Project details
Scientific Abstract
Liver biology and liver diseases are difficult to study using current in vitro models. We developed a new method to isolate and expand self-renewing liver organoids from the embryonic liver. Within this project we aim to understand how microbiome-associated signaling pathways influence maturation, injury and regeneration of the liver by using these organoids. Thus this project will provide new insights in the critical role of liver-gut communication and potentially hepatic disease development.
Involved:
Contributing FAU Organisations:
Professur für Gastrointestinale Pathophysiologie
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
