Wank I, Mittmann C, Kreitz S, Chestnykh D, Mühle C, Kornhuber J, Ludwig A, Kalinichenko L, Müller CP, Heß A (2024)
Publication Type: Journal article
Publication year: 2024
Book Volume: 253
Article Number: 109948
DOI: 10.1016/j.neuropharm.2024.109948
Alcohol consumption is a widespread phenomenon throughout the world. However, how recreational alcohol use evolves into alcohol use disorder (AUD) remains poorly understood. The Smpd3 gene and its coded protein neutral sphingomyelinase (NSM) are associated with alcohol consumption in humans and alcohol-related behaviors in mice, suggesting a potential role in this transition. Using multiparametric magnetic resonance imaging, we characterized the role of NSM in acute and chronic effects of alcohol on brain anatomy and function in female mice. Chronic voluntary alcohol consumption (16 vol% for at least 6 days) affected brain anatomy in WT mice, reducing regional structure volume predominantly in cortical regions. Attenuated NSM activity prevented these anatomical changes. Functional MRI linked these anatomical adaptations to functional changes: Chronic alcohol consumption in mice significantly modulated resting state functional connectivity (RS FC) in response to an acute ethanol challenge (i.p. bolus of 2 g kg−1) in heterozygous NSM knockout (Fro), but not in WT mice. Acute ethanol administration in alcohol-naïve WT mice significantly decreased RS FC in cortical and brainstem regions, a key finding that was amplified in Fro mice. Regarding direct pharmacological effects, acute ethanol administration increased the regional cerebral blood volume (rCBV) in many brain areas. Here, chronic alcohol consumption otherwise attenuated the acute rCBV response in WT mice but enhanced it in Fro mice. Altogether, these findings suggest a differential role for NSM in acute and chronic functional brain responses to alcohol. Therefore, targeting NSM may be useful in the prevention or treatment of AUD.
APA:
Wank, I., Mittmann, C., Kreitz, S., Chestnykh, D., Mühle, C., Kornhuber, J.,... Heß, A. (2024). Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity. Neuropharmacology, 253. https://doi.org/10.1016/j.neuropharm.2024.109948
MLA:
Wank, Isabel, et al. "Neutral sphingomyelinase controls acute and chronic alcohol effects on brain activity." Neuropharmacology 253 (2024).
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