Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function
Poupardin R, Wolf M, Maeding N, Paniushkina L, Geissler S, Bergese P, Witwer KW, Schallmoser K, Fuhrmann G, Strunk D (2024)
Publication Type: Journal article, Review article
Publication year: 2024
Journal
Abstract
The evolution of extracellular vesicle (EV) research has introduced nanotechnology into biomedical cell communication science while recognizing what is formerly considered cell “dust” as constituting an entirely new universe of cell signaling particles. To display the global EV research landscape, a systematic review of 20 364 original research articles selected from all 40 684 EV-related records identified in PubMed 2013–2022 is performed. Machine-learning is used to categorize the high-dimensional data and further dissected significant associations between EV source, isolation method, cargo, and function. Unexpected correlations between these four categories indicate prevalent experimental strategies based on cargo connectivity with function of interest being associated with certain EV sources or isolation strategies. Conceptually relevant association of size-based EV isolation with protein cargo and uptake function will guide strategic conclusions enhancing future EV research and product development. Based on this study, an open-source database is built to facilitate further analysis with conventional or AI tools to identify additional causative associations of interest.
Authors with CRIS profile
Involved external institutions
Paracelsus Medizinische Privatuniversität
Austria (AT)
Università degli Studi di Brescia
Italy (IT)
Berliner Institut für Gesundheitsforschung (BIH)
Germany (DE)
Johns Hopkins Hospital
United States (USA) (US)
Austria (AT)
Università degli Studi di Brescia
Italy (IT)
Berliner Institut für Gesundheitsforschung (BIH)
Germany (DE)
Johns Hopkins Hospital
United States (USA) (US)
How to cite
APA:
Poupardin, R., Wolf, M., Maeding, N., Paniushkina, L., Geissler, S., Bergese, P.,... Strunk, D. (2024). Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.202303941
MLA:
Poupardin, Rodolphe, et al. "Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function." Advanced Healthcare Materials (2024).
BibTeX: Download