Daniel C (2008)
Publication Type: Journal article
Publication year: 2008
Book Volume: 74
Pages Range: 551-553
Journal Issue: 5
DOI: 10.1038/ki.2008.290
Fibrosis is a common feature of chronic kidney diseases that is mediated by matrix-producing myofibroblasts. One potential origin of myofibroblasts is epithelial-mesenchymal transition (EMT) of tubuloepithelial cells. Transforming growth factor-β (TGF-β) is a key factor inducing EMT. Carvajal et al. demonstrate that angiotensin II induces EMT by classical stimulation of TGF-β and also by a TGF-β-independent pathway, both signaling via Smad molecules. Therefore, blockade of angiotensin II is more than lowering of blood pressure and inhibition of TGF-β stimulation.
APA:
Daniel, C. (2008). Blocking of angiotensin II is more than blocking of transforming growth factor-β. Kidney International, 74(5), 551-553. https://doi.org/10.1038/ki.2008.290
MLA:
Daniel, Christoph. "Blocking of angiotensin II is more than blocking of transforming growth factor-β." Kidney International 74.5 (2008): 551-553.
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