Hugo C, Daniel C (2009)
Publication Type: Journal article
Publication year: 2009
Book Volume: 111
Pages Range: e61-e66
Journal Issue: 3
DOI: 10.1159/000198235
Thrombospondins (TSPs) are multifunctional matricellular glycoproteins which are involved in the regulation of angiogenesis, proliferation, apoptosis, the NO-cGMP-dependent protein kinase pathway and transforming growth factor (TGF) β activation. The TSP family consists of 5 members, but currently only data on effects of TSP-1 and TSP-2 in renal disease are available. Both TSPs are hardly expressed within the healthy renal cortex and can be upregulated during renal disease. Using different animal models for renal disease, TSP-1 and -2 were found to be important regulators of pathophysiological changes during renal disease with similar and contrary effects. TSP-1 is a major activator for TGF-β resulting in profibrotic effects in the injured kidney. In contrast, TSP-2 lacks the ability for its activation. Proapoptotic actions of TSP-1 were found during renal ischemia/reperfusion injury. While TSP-1 exerts proinflammatory actions, the currently available data for TSP-2 propose anti-inflammatory effects for this molecule. Both TSPs are known angiogenesis inhibitors, which could be proved for TSP-2, but antiangiogenic effects for TSP-1 were only evident by treatment with TSP-1 peptides in renal disease. In addition, TSP-2 can inhibit cell proliferation and matrix metalloproteinase 2 activity. © 2009 S. Karger AG, Basel.
APA:
Hugo, C., & Daniel, C. (2009). Thrombospondin in renal disease. Nephron Experimental Nephrology, 111(3), e61-e66. https://doi.org/10.1159/000198235
MLA:
Hugo, Christian, and Christoph Daniel. "Thrombospondin in renal disease." Nephron Experimental Nephrology 111.3 (2009): e61-e66.
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