Declining frequency of sensitization to fragrance mixes I and II: IVDK-data of the years 2012-2021.
Geier J, Schubert S, Rieker-Schwienbacher J, Brans R, Weisshaar E, Kränke B, Brockow K, Ruёff F, Recke A, Uter W (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 90
Pages Range: 470-478
Journal Issue: 5
DOI: 10.1111/cod.14493
Abstract
BACKGROUND: EU Commission Regulation 2017/1410 prohibits using atranol and chloroatranol, the main allergens in Evernia prunastri (oakmoss), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) in cosmetic products. Oakmoss absolute is contained in fragrance mix (FM) I and HICC in FM II which are patch tested as screening mixtures in the baseline series. OBJECTIVE: To describe the time trends of reaction frequencies to both FMs as well as to their components in FM-positive patients. METHODS: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2012-2021. RESULTS: Positive reactions to FM I (FM II) declined from 9.1% (4.7%) in 2012 to 4.6% (3.0%) in 2021. Full breakdown tests were performed in 24% (FM I) and 31% (FM II), respectively, of the mix-positive patients. From this data, frequencies of sensitization to the 14 single fragrances of FM I and FM II were calculated. For the majority, a decline was noted from 2012/2013 to 2020/2021, for oakmoss absolute 1.9%-0.8% and for HICC 1.8%-0.9%. CONCLUSION: EU Commission Regulation 2017/1410 was an effective measure. However, our data have some limitations, possibly causing underestimation of sensitization frequencies to fragrances.
Authors with CRIS profile
Involved external institutions
Medizinische Universität Graz
Austria (AT)
Technische Universität München (TUM)
Germany (DE)
Klinikum der Universität München
Germany (DE)
Universitätsklinikum Göttingen
Germany (DE)
Universität zu Lübeck
Germany (DE)
Klinikum Stuttgart
Germany (DE)
Universität Osnabrück
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Austria (AT)
Technische Universität München (TUM)
Germany (DE)
Klinikum der Universität München
Germany (DE)
Universitätsklinikum Göttingen
Germany (DE)
Universität zu Lübeck
Germany (DE)
Klinikum Stuttgart
Germany (DE)
Universität Osnabrück
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
How to cite
APA:
Geier, J., Schubert, S., Rieker-Schwienbacher, J., Brans, R., Weisshaar, E., Kränke, B.,... Uter, W. (2024). Declining frequency of sensitization to fragrance mixes I and II: IVDK-data of the years 2012-2021. Contact Dermatitis, 90(5), 470-478. https://doi.org/10.1111/cod.14493
MLA:
Geier, Johannes, et al. "Declining frequency of sensitization to fragrance mixes I and II: IVDK-data of the years 2012-2021." Contact Dermatitis 90.5 (2024): 470-478.
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