Disease-associated astrocyte epigenetic memory promotes CNS pathology
Lee HG, Rone JM, Li Z, Akl CF, Shin SW, Lee JH, Flausino LE, Pernin F, Chao CC, Kleemann KL, Srun L, Illouz T, Giovannoni F, Charabati M, Sanmarco LM, Kenison JE, Piester G, Zandee SE, Antel JP, Rothhammer V, Wheeler MA, Prat A, Clark IC, Quintana FJ (2024)
Publication Type: Journal article
Publication year: 2024
Journal
DOI: 10.1038/s41586-024-07187-5
Abstract
In an experimental autoimmune encephalomyelitis model in mice, a subset of astrocytes retains an epigenetically regulated memory of past inflammation, causing exacerbated inflammation upon subsequent rechallenge.
Involved external institutions
Veterans Affairs Healthcare System Boston and Harvard Medical School
United States (USA) (US)
Montreal Neurological Institute and Hospital (MNI, The Neuro)
Canada (CA)
Centre hospitalier de l'Université de Montréal (CHUM)
Canada (CA)
University of Portsmouth
United Kingdom (GB)
United States (USA) (US)
Montreal Neurological Institute and Hospital (MNI, The Neuro)
Canada (CA)
Centre hospitalier de l'Université de Montréal (CHUM)
Canada (CA)
University of Portsmouth
United Kingdom (GB)
How to cite
APA:
Lee, H.G., Rone, J.M., Li, Z., Akl, C.F., Shin, S.W., Lee, J.H.,... Quintana, F.J. (2024). Disease-associated astrocyte epigenetic memory promotes CNS pathology. Nature. https://doi.org/10.1038/s41586-024-07187-5
MLA:
Lee, Hong Gyun, et al. "Disease-associated astrocyte epigenetic memory promotes CNS pathology." Nature (2024).
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