Methylphenidate and Sleep Difficulties in Children and Adolescents With ADHD: Results From the 2-Year Naturalistic Pharmacovigilance ADDUCE Study

Häge A, Man KK, Inglis SK, Buitelaar J, Carucci S, Danckaerts M, Dittmann RW, Falissard B, Garas P, Hollis C, Konrad K, Kovshoff H, Liddle E, McCarthy S, Neubert A, Nagy P, Rosenthal E, Sonuga-Barke EJ, Zuddas A, Wong IC, Coghill D, Banaschewski T (2024)

Publication Type: Journal article

Publication year: 2024

Journal

DOI: 10.1177/10870547241232337

Abstract

Objective: Short-term RCTs have demonstrated that MPH-treatment significantly reduces ADHD-symptoms, but is also associated with adverse events, including sleep problems. However, data on long-term effects of MPH on sleep remain limited. Methods: We performed a 2-year naturalistic prospective pharmacovigilance multicentre study. Participants were recruited into three groups: ADHD patients intending to start MPH-treatment (MPH-group), those not intending to use ADHD-medication (no-MPH-group), and a non-ADHD control-group. Sleep problems were assessed with the Children’s-Sleep-Habits-Questionnaire (CSHQ). Results: 1,410 participants were enrolled. Baseline mean CSHQ-total-sleep-scores could be considered clinically significant for the MPH-group and the no-MPH-group, but not for controls. The only group to show a significant increase in any aspect of sleep from baseline to 24-months was the control-group. Comparing the MPH- to the no-MPH-group no differences in total-sleep-score changes were found. Conclusion: Our findings support that sleep-problems are common in ADHD, but don’t suggest significant negative long-term effects of MPH on sleep.

Authors with CRIS profile

Involved external institutions

University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Université Paris-Saclay France (FR) Semmelweis University / Semmelweis Egyetem Hungary (HU) University of Nottingham United Kingdom (GB) Universitätsklinikum Aachen (UKA) Germany (DE) University of Southampton United Kingdom (GB) University College Cork (UCC) Ireland (IE) Bethesda Children’s Hospital / Bethesda Kórház Alapítvány Hungary (HU) Evelina London Children's Hospital United Kingdom (GB) King’s College London United Kingdom (GB) Università degli Studi di Cagliari Italy (IT) University of Hong Kong (HKU) / 香港大學 Hong Kong (HK) University of Dundee United Kingdom (GB) Donders Institute for Brain, Cognition and Behaviour Netherlands (NL) University College London (UCL) United Kingdom (GB)

How to cite

APA:

Häge, A., Man, K.K., Inglis, S.K., Buitelaar, J., Carucci, S., Danckaerts, M.,... Banaschewski, T. (2024). Methylphenidate and Sleep Difficulties in Children and Adolescents With ADHD: Results From the 2-Year Naturalistic Pharmacovigilance ADDUCE Study. Journal of Attention Disorders. https://doi.org/10.1177/10870547241232337

MLA:

Häge, Alexander, et al. "Methylphenidate and Sleep Difficulties in Children and Adolescents With ADHD: Results From the 2-Year Naturalistic Pharmacovigilance ADDUCE Study." Journal of Attention Disorders (2024).

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