Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact
Coca-Pelaz A, Rodrigo JP, Agaimy A, Williams MD, Saba NF, Nuyts S, Randolph GW, López F, Vander Poorten V, Kowalski LP, Civantos FJ, Zafereo ME, Mäkitie AA, Cohen O, Nixon IJ, Rinaldo A, Ferlito A (2024)
Publication Language: English
Publication Type: Journal article, Review article
Publication year: 2024
Journal
DOI: 10.1007/s00428-024-03752-5
Abstract
Poorly differentiated thyroid carcinomas (PDTC) are rare diseases; nevertheless, they account for the majority of deaths from non-anaplastic follicular cell-derived thyroid carcinomas. Establishing the diagnosis and treatment of PDTC is challenging given the low incidence and the lack of standardization of diagnostic criteria. These limitations hamper the ability to compare therapeutic modalities and outcomes between recent and older studies. Recently, the 5th edition of the classification of endocrine tumors has been published, which includes changes in nomenclature and the addition of the disease entity of “differentiated high-grade follicular cell-derived carcinomas”. On the other hand, the recently witnessed advances in molecular diagnostics have enriched therapeutic options and improved prognosis for patients. We herein review the various historical variations and evolution in the diagnostic criteria for PDTC. This systematic review attempts to clarify the evolution of the histological and molecular characteristics of this disease, its prognosis, as well as its treatment options.
Authors with CRIS profile
Involved external institutions
Massachusetts Eye and Ear (MEE)
United States (USA) (US)
Helsingin yliopisto / University of Helsinki
Finland (FI)
Emory University
United States (USA) (US)
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
Policlinico Città di Udine
Italy (IT)
International Head and Neck Scientific Group
Germany (DE)
Central University Hospital of Asturias
Spain (ES)
A.C.Camargo Cancer Center
Brazil (BR)
Sylvester Comprehensive Cancer Center
United States (USA) (US)
University of Texas MD Anderson Cancer Center
United States (USA) (US)
Samson Assuta Ashdod University Hospital / Assuta Ashdod Medical Center
Israel (IL)
University of Edinburgh
United Kingdom (GB)
United States (USA) (US)
Helsingin yliopisto / University of Helsinki
Finland (FI)
Emory University
United States (USA) (US)
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
Policlinico Città di Udine
Italy (IT)
International Head and Neck Scientific Group
Germany (DE)
Central University Hospital of Asturias
Spain (ES)
A.C.Camargo Cancer Center
Brazil (BR)
Sylvester Comprehensive Cancer Center
United States (USA) (US)
University of Texas MD Anderson Cancer Center
United States (USA) (US)
Samson Assuta Ashdod University Hospital / Assuta Ashdod Medical Center
Israel (IL)
University of Edinburgh
United Kingdom (GB)
How to cite
APA:
Coca-Pelaz, A., Rodrigo, J.P., Agaimy, A., Williams, M.D., Saba, N.F., Nuyts, S.,... Ferlito, A. (2024). Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact. Virchows Archiv. https://doi.org/10.1007/s00428-024-03752-5
MLA:
Coca-Pelaz, Andrés, et al. "Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact." Virchows Archiv (2024).
BibTeX: Download