Malignant transformation of a dysembryoplastic neuroepithelial tumor (DNET) characterized by genome-wide methylation analysis
Heiland DH, Staszewski O, Hirsch M, Masalha W, Franco P, Grauvogel J, Capper D, Schrimpf D, Urbach H, Weyerbrock A (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 75
Pages Range: 358-365
Journal Issue: 4
DOI: 10.1093/jnen/nlw007
Abstract
Dysembryoplastic neuroepithelial tumors (DNET) are considered to be rare, benign, and associated with chronic epilepsy. We present the case of a 28-year-old man with a history of epilepsy since age 12. Surgery of an occipital cortical lesion in 2009 revealed a DNET. Five years later, a recurrent tumor at the edge of the resection cavity was removed, and the tissue underwent an intensive diagnostic workup. The first tumor was unequivocally characterized as a DNET, but neuropathological diagnostics of the recurrent tumor revealed a glioblastoma. After 6 months, another recurrent tumor was detected next to the location of the original tumor, and this was also resected. An Illumina 450 K beadchip methylation array was performed to characterize all of the tumors. The methylation profile of these tumors significantly differed from other glioblastoma and epilepsy-associated tumor profiles and revealed a DNET-like methylation profile. Thus, molecular characterization of these recurrent tumors suggests malignant transformation of a previously benign DNET. We found increased copy number changes in the recurrent DNET tumors after malignant transformation. Modern high-throughput analysis adds essential molecular information in addition to standard histopathology for proper identification of rare brain tumors that present with an unusual clinical course.
Involved external institutions
Universitätsklinikum Freiburg
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
How to cite
APA:
Heiland, D.H., Staszewski, O., Hirsch, M., Masalha, W., Franco, P., Grauvogel, J.,... Weyerbrock, A. (2016). Malignant transformation of a dysembryoplastic neuroepithelial tumor (DNET) characterized by genome-wide methylation analysis. Journal of Neuropathology and Experimental Neurology, 75(4), 358-365. https://doi.org/10.1093/jnen/nlw007
MLA:
Heiland, Dieter Henrik, et al. "Malignant transformation of a dysembryoplastic neuroepithelial tumor (DNET) characterized by genome-wide methylation analysis." Journal of Neuropathology and Experimental Neurology 75.4 (2016): 358-365.
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