Diagnostic Utility of Interleukin-6 in Early-Onset Sepsis among Term Newborns: Impact of Maternal Risk Factors and CRP Evaluation.

Schleier M, Lubig J, Kehl S, Hébert S, Wölfle J, van der Donk A, Bär A, Reutter HM, Hepp T, Morhart P (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Children MDPI

Book Volume: 11

Journal Issue: 1

DOI: 10.3390/children11010053

Abstract

(1) Background: Interleukin-6 (IL-6) levels act as an early infection marker preceding C-reactive protein (CRP) elevation. This study seeks to analyze IL-6 behavior in suspected early-onset sepsis (EOS) cases among term newborns, comparing it to that of CRP and evaluating IL-6's diagnostic utility. We also aim to assess the impact of maternal risk factors on EOS in term newborns, quantifying their influence for informed decision making. (2) Methods: The retrospective data analysis included 533 term newborns who were admitted to our hospital because of suspected EOS. IL-6, CRP, and the impact of maternal risk factors were analyzed in the context of EOS using binomial test, Chi-squared test, logistic and linear regression. (3) Results: In the cases of EOS, both IL-6 and CRP were elevated. The increase in CRP can be predicted by the initial increase in IL-6 levels. Among the assessed risk factors, intrapartum maternal fever (adjusted odds ratio 18.1; 95% CI (1.7-4.1)) was identified as the only risk factor significantly associated with EOS. (4) Conclusions: Employing IL-6 as an early infection marker enhanced EOS diagnostic precision due to its detectable early rise. However, caution is required, as elevations in IL-6 and CRP levels do not exclusively indicate EOS. Increased CRP levels in healthy newborns with maternal risk factors may be attributed to dynamics of vaginal labor.

Authors with CRIS profile

Maria Schleier Professur für Neonatologie Julia Lubig Department of Paediatrics and Adolescent Medicine Sven Kehl Department of Obstetrics and Gynaecology Steven Hébert Department of Paediatrics and Adolescent Medicine Joachim Wölfle Lehrstuhl für Kinder- und Jugendmedizin Adriana van der Donk Professur für Neonatologie Alisa Bär Professur für Neonatologie Heiko Martin Reutter Professur für Neonatologie Tobias Hepp Interdisziplinäres Zentrum für Klinische Forschung IZKF-Förderlinien

How to cite

APA:

Schleier, M., Lubig, J., Kehl, S., Hébert, S., Wölfle, J., van der Donk, A.,... Morhart, P. (2023). Diagnostic Utility of Interleukin-6 in Early-Onset Sepsis among Term Newborns: Impact of Maternal Risk Factors and CRP Evaluation. Children, 11(1). https://dx.doi.org/10.3390/children11010053

MLA:

Schleier, Maria, et al. "Diagnostic Utility of Interleukin-6 in Early-Onset Sepsis among Term Newborns: Impact of Maternal Risk Factors and CRP Evaluation." Children 11.1 (2023).

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