A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae
Imambocus BN, Zhou F, Formozov A, Wittich A, Tenedini FM, Hu C, Sauter K, Macarenhas Varela E, Herédia F, Casimiro AP, Macedo A, Schlegel P, Yang CH, Miguel-Aliaga I, Wiegert JS, Pankratz MJ, Gontijo AM, Cardona A, Soba P (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 32
Pages Range: 149-163.e8
Journal Issue: 1
DOI: 10.1016/j.cub.2021.10.069
Abstract
Animals display selective escape behaviors when faced with environmental threats. Selection of the appropriate response by the underlying neuronal network is key to maximizing chances of survival, yet the underlying network mechanisms are so far not fully understood. Using synapse-level reconstruction of the Drosophila larval network paired with physiological and behavioral readouts, we uncovered a circuit that gates selective escape behavior for noxious light through acute and input-specific neuropeptide action. Sensory neurons required for avoidance of noxious light and escape in response to harsh touch, each converge on discrete domains of neuromodulatory hub neurons. We show that acute release of hub neuron-derived insulin-like peptide 7 (Ilp7) and cognate relaxin family receptor (Lgr4) signaling in downstream neurons are required for noxious light avoidance, but not harsh touch responses. Our work highlights a role for compartmentalized circuit organization and neuropeptide release from regulatory hubs, acting as central circuit elements gating escape responses.
Authors with CRIS profile
Involved external institutions
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
New University of Lisbon / Universidade Nova de Lisboa
Portugal (PT)
Duke University
United States (USA) (US)
Medical Research Council
United Kingdom (GB)
Janelia Research Campus
United States (USA) (US)
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
New University of Lisbon / Universidade Nova de Lisboa
Portugal (PT)
Duke University
United States (USA) (US)
Medical Research Council
United Kingdom (GB)
Janelia Research Campus
United States (USA) (US)
How to cite
APA:
Imambocus, B.N., Zhou, F., Formozov, A., Wittich, A., Tenedini, F.M., Hu, C.,... Soba, P. (2022). A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. Current Biology, 32(1), 149-163.e8. https://doi.org/10.1016/j.cub.2021.10.069
MLA:
Imambocus, Bibi Nusreen, et al. "A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae." Current Biology 32.1 (2022): 149-163.e8.
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