Assessment of Osteogenic Exercise Efficacy via Bone Turnover Markers in Premenopausal Women: A Randomized Controlled Trial

Sanchez-Trigo H, Kemmler W, Duque G, Sañudo B (2024)

Publication Type: Journal article

Publication year: 2024

Journal

International Journal of Sport Nutrition and Exercise Metabolism Human Kinetics

Book Volume: 34

Pages Range: 20-29

Journal Issue: 1

DOI: 10.1123/ijsnem.2023-0104

Abstract

Assessing bone’s response to physical activity interventions is challenging. This randomized controlled trial investigates if changes in bone turnover markers can offer an early evaluation of a physical activity intervention’s effectiveness in improving bone mineral density (BMD) in premenopausal women. Participants in the intervention group (n = 27, with 24 completing the trial) were instructed to walk at least 10, 000 steps every day on a brisk walk and to execute 60 jumps daily, each surpassing 4g of acceleration, using an accelerometer-based wearable device. Meanwhile, the control group (n = 26, with 18 completing the trial) continued with their usual lifestyle. Bone turnover markers, comprising of C-terminal telopeptide of Type I collagen, procollagen Type 1 N-terminal propeptide, and total osteocalcin (carboxylated and undercarboxylated) were measured at baseline and midway through the intervention (3 months). Dual-energy X-ray absorptiometry scans of the hip and lumbar spine were conducted at baseline and the end of the intervention (6 months) to estimate BMD. Analysis of covariance exhibited significant differences between groups in procollagen Type 1 N-terminal propeptide (-6.74 μg/L, p = .023) and C-terminal telopeptide of Type I collagen (-83 ng/L, p = .043) after 3 months, and in femoral neck BMD (+0.024 g/cm2, p = .016), total hip BMD (+0.036 g/cm2, p = .004), and lumbar spine BMD (+0.026 g/cm2, p = .020) after 6 months. A significant correlation (r = -.73; p < .001) was detected between reductions in C-terminal telopeptide of Type I collagen and increases in femoral neck BMD. In conclusion, this intervention improved BMD in premenopausal women, with bone turnover markers potentially useful for early intervention assessment, though further research is needed.

Authors with CRIS profile

Wolfgang Kemmler Lehrstuhl für Medizinische Physik und Mikrogewebetechnik

Involved external institutions

University of Seville / Universidad de Sevilla ES Spain (ES) McGill University Health Centre (MUHC) / Centre universitaire de santé McGill CA Canada (CA)

How to cite

APA:

Sanchez-Trigo, H., Kemmler, W., Duque, G., & Sañudo, B. (2024). Assessment of Osteogenic Exercise Efficacy via Bone Turnover Markers in Premenopausal Women: A Randomized Controlled Trial. International Journal of Sport Nutrition and Exercise Metabolism, 34(1), 20-29. https://doi.org/10.1123/ijsnem.2023-0104

MLA:

Sanchez-Trigo, Horacio, et al. "Assessment of Osteogenic Exercise Efficacy via Bone Turnover Markers in Premenopausal Women: A Randomized Controlled Trial." International Journal of Sport Nutrition and Exercise Metabolism 34.1 (2024): 20-29.

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