Vitamin D3 resolved human and experimental asthma via B lymphocyte-induced maturation protein 1 in T cells and innate lymphoid cells.

Grund J, Krammer S, Yang Z, Mitländer H, Rauh M, Zirlik S, Kiefer A, Zimmermann T, Rieker R, Geppert CI, Papadopoulos NG, Neurath-Finotto S (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Journal of Allergy and Clinical Immunology: Global ScienceDirect/Elsevier

Book Volume: 2

Journal Issue: 3

DOI: 10.1016/j.jacig.2023.100099

Abstract

BACKGROUND: Vitamin D3 (VitD3) is known to have immunomodulatory functions, and VitD3 deficiency is associated with more severe asthma. OBJECTIVE: We aimed to assess the immunoregulatory effects of VitD3 food supplementation on asthma manifestation, with particular focus on T cells and type 2 innate lymphoid cells. METHODS: Preschool children and adult asthmatic cohorts were analyzed in the context of VitD3 supplementation and serum levels. In a murine model of ovalbumin-induced asthma, effects of diet VitD3 sufficiency and deficiency on T cells and type 2 innate lymphoid cells immune mechanisms were investigated. RESULTS: We found less severe and better-controlled asthma phenotypes along with reduced need for steroid medication in preschool children and asthmatic adults with VitD3 supplementation. VitD3 serum levels correlated with B lymphocyte-induced maturation protein 1 (Blimp-1) expression in blood peripheral mononuclear cells. VitD3-supplement-fed mice showed decreased asthmatic traits, with a decrease in IgE serum levels, reduced airway mucus, and increased IL-10 production by lung cells. Furthermore, we discovered an upregulation of effector T cells and Blimp-1+ lung tissue-resident memory T cells as well as induction of anti-inflammatory Blimp-1+ lung innate lymphoid cells producing IL-10. CONCLUSION: Supplementing VitD3 resulted in amelioration of clinical asthma manifestations in human studies as well as in experimental allergic asthma, indicating that VitD3 shifts proinflammatory immune responses to anti-inflammatory immune responses via upregulating Blimp-1 in lung innate lymphoid cells and tissue-resident memory cells.

Authors with CRIS profile

Janina Grund Professur für Molekulare Pneumologie Susanne Krammer Department of Molecular Pneumology Zuqin Yang Department of Molecular Pneumology Hannah Mitländer Professur für Molekulare Pneumologie Manfred Rauh Department of Paediatrics and Adolescent Medicine Sabine Zirlik Medizinische Fakultät Theodor Zimmermann Medizinische Fakultät Ralf Rieker Institute of Pathology Carol-Immanuel Geppert Institute of Pathology Susetta Neurath-Finotto Professur für Molekulare Pneumologie

Involved external institutions

National and Kapodistrian University of Athens GR Greece (GR)

How to cite

APA:

Grund, J., Krammer, S., Yang, Z., Mitländer, H., Rauh, M., Zirlik, S.,... Neurath-Finotto, S. (2023). Vitamin D3 resolved human and experimental asthma via B lymphocyte-induced maturation protein 1 in T cells and innate lymphoid cells. Journal of Allergy and Clinical Immunology: Global, 2(3). https://doi.org/10.1016/j.jacig.2023.100099

MLA:

Grund, Janina, et al. "Vitamin D3 resolved human and experimental asthma via B lymphocyte-induced maturation protein 1 in T cells and innate lymphoid cells." Journal of Allergy and Clinical Immunology: Global 2.3 (2023).

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