General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination

Elfinger M, Bauer C, Schmauch J, Moritz M, Wichmann C, Papp C, Kempe R (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Advanced Synthesis & Catalysis Wiley

DOI: 10.1002/adsc.202301179

Abstract

Amines are a very important class of compounds and the selective synthesis of differently substituted primary, secondary and tertiary alkyl amines is challenging. Here we present the synthesis of primary, secondary, and tertiary alkyl amines from ammonia and alcohols, aldehydes, ketones and hydrogen by combining borrowing hydrogen or hydrogen autotransfer and reductive amination with hydrogen. The key is a nanostructured, bimetallic Co/Sc catalyst able to mediate both reactions or concepts efficiently. We observe a broad product scope, a very good functional group tolerance, upscaling is easily accomplished and our catalyst is reusable.

Authors with CRIS profile

Michael Moritz Lehrstuhl für Physikalische Chemie II Christoph Wichmann Collaborative Research Centre 1452/1 Catalysis at Liquid Interfaces (CLINT) Christian Papp Lehrstuhl für Physikalische Chemie II

Involved external institutions

Universität Bayreuth DE Germany (DE) Universität des Saarlandes (UdS) DE Germany (DE)

How to cite

APA:

Elfinger, M., Bauer, C., Schmauch, J., Moritz, M., Wichmann, C., Papp, C., & Kempe, R. (2023). General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination. Advanced Synthesis & Catalysis. https://doi.org/10.1002/adsc.202301179

MLA:

Elfinger, Matthias, et al. "General Synthesis of Alkyl Amines via Borrowing Hydrogen and Reductive Amination." Advanced Synthesis & Catalysis (2023).

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