Harder S, Langer J (2023)
Publication Type: Journal article, Review article
Publication year: 2023
DOI: 10.1038/s41570-023-00548-0
More than a century old, magnesium Grignard reagents remain essential to the toolbox of organic chemists. Although similar reagents with the neighbouring group 2 metal Ca have been explored, the considerably higher polarity and reactivity of the Ca–C bond result in undesired decomposition pathways. Ca Grignard reagents have found academic interest but have never fully developed into an established synthetic tool. Recent research activities, however, provide facile access to these highly reactive organocalcium species, including in situ preparation and ball milling approaches to tackle the challenge of controlling their extreme sensitivity. Heavier Grignard reagents are not just more reactive but profit from unique chemical transformations. Insight into the transition metal-like properties of Ca, Sr and Ba is only just emerging. Considering the rapidly developing field of alkaline-earth metal-mediated catalysis, heavy Grignard reagents will probably have a bright future. [Figure not available: see fulltext.].
APA:
Harder, S., & Langer, J. (2023). Opportunities with calcium Grignard reagents and other heavy alkaline-earth organometallics. Nature Reviews Chemistry. https://doi.org/10.1038/s41570-023-00548-0
MLA:
Harder, Sjoerd, and Jens Langer. "Opportunities with calcium Grignard reagents and other heavy alkaline-earth organometallics." Nature Reviews Chemistry (2023).
BibTeX: Download