Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease

Iyer K, Erkert L, Becker C (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Frontiers in Cell and Developmental Biology Frontiers Media

Book Volume: 11

Article Number: 1228283

DOI: 10.3389/fcell.2023.1228283

Abstract

Intestinal epithelial cells (IECs) perform several physiological and metabolic functions at the epithelial barrier. IECs also play an important role in defining the overall immune functions at the mucosal region. Pattern recognition receptors (PRRs) on the cell surface and in other cellular compartments enable them to sense the presence of microbes and microbial products in the intestinal lumen. IECs are thus at the crossroads of mediating a bidirectional interaction between the microbial population and the immune cells present at the intestinal mucosa. This communication between the microbial population, the IECs and the underlying immune cells has a profound impact on the overall health of the host. In this review, we focus on the various PRRs present in different cellular compartments of IECs and discuss the recent developments in the understanding of their role in microbial recognition. Microbial recognition and signaling at the epithelial barrier have implications in the maintenance of intestinal homeostasis, epithelial barrier function, maintenance of commensals, and the overall tolerogenic function of PRRs in the gut mucosa. We also highlight the role of an aberrant microbial sensing at the epithelial barrier in the pathogenesis of inflammatory bowel disease (IBD) and the development of colorectal cancer.

Authors with CRIS profile

Lena Erkert Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Christoph Becker Professur für Molekulare Gastroenterologie

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

A093: Epithelial ACLY as a key immunometabolic regulator of intestinal inflammation July 1, 2023 - Dec. 31, 2025 A076: Elucidating the regulation and function of Gasdermin C in intestinal infection and inflammation Feb. 1, 2020 - Jan. 31, 2023

How to cite

APA:

Iyer, K., Erkert, L., & Becker, C. (2023). Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1228283

MLA:

Iyer, Krishna, Lena Erkert, and Christoph Becker. "Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease." Frontiers in Cell and Developmental Biology 11 (2023).

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