HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells

Stab V, Stahl-Hennig C, Enßer A, Richel E, Fraedrich K, Sauermann U, Tippler B, Klein F, Burton DR, Tenbusch M, Überla K (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Cell Reports Medicine Elsevier

Book Volume: 4

Article Number: 101201

Journal Issue: 10

DOI: 10.1016/j.xcrm.2023.101201

Abstract

Neutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge virus. After natural exposure to HIV-1, such a reduction of the number of first infection events should be sufficient to provide sterilizing immunity in the strictest sense in most of the exposed individuals. Since blocking infection of the first cells avoids the formation of latently infected cells and reduces the risk of emergence of antibody-resistant mutants, it may be the best mode of protection.

Authors with CRIS profile

Armin Enßer Institute of Clinical and Molecular Virology Elie Richel Institute of Clinical and Molecular Virology

Involved external institutions

Deutsches Primatenzentrum (DPZ), Leibniz-Institut für Primatenforschung DE Germany (DE) Ruhr-Universität Bochum (RUB) DE Germany (DE) Universitätsklinikum Köln DE Germany (DE) Scripps Research Institute (TSRI) US United States (USA) (US)

How to cite

APA:

Stab, V., Stahl-Hennig, C., Enßer, A., Richel, E., Fraedrich, K., Sauermann, U.,... Überla, K. (2023). HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells. Cell Reports Medicine, 4(10). https://doi.org/10.1016/j.xcrm.2023.101201

MLA:

Stab, Viktoria, et al. "HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells." Cell Reports Medicine 4.10 (2023).

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