Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease

Grieshaber-Bouyer R, Nigrovic PA (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 10

Article Number: 346

Journal Issue: MAR

DOI: 10.3389/fimmu.2019.00346

Abstract

Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneous, offering possibilities for selective intervention. Here we review heterogeneity within the neutrophil population as well as in the pathways mediating neutrophil recruitment to inflamed tissues with a view to outlining opportunities for therapeutic manipulation in inflammatory disease.

Authors with CRIS profile

Ricardo Grieshaber Bouyer

Involved external institutions

Brigham and Women's Hospital (BWH) US United States (USA) (US)

How to cite

APA:

Grieshaber-Bouyer, R., & Nigrovic, P.A. (2019). Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease. Frontiers in Immunology, 10(MAR). https://doi.org/10.3389/fimmu.2019.00346

MLA:

Grieshaber-Bouyer, Ricardo, and Peter A. Nigrovic. "Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease." Frontiers in Immunology 10.MAR (2019).

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