An Increase in Mucin2 Expression Is Required for Colon Cancer Progression Mediated by L1
Saha A, Gavert N, Brabletz T, Ben-Ze’ev A (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 24
Article Number: 13418
Journal Issue: 17
Abstract
An induction in the expression of the cell adhesion receptor L1, a Wnt target gene, is a characteristic feature of Wnt/β-catenin activation in colon cancer cells at later stages of the disease. We investigated the proteins secreted following L1 expression in colon cancer cells and identified Mucin2 among the most abundant secreted proteins. We found that suppressing Mucin2 expression in L1-expressing colon cancer cells inhibits cell proliferation, motility, tumorigenesis, and liver metastasis. We detected several signaling pathways involved in Mucin2 induction in L1-expressing cells. In human colon cancer tissue, Mucin2 expression was significantly reduced or lost in the adenocarcinoma tissue, while in the mucinous subtype of colon cancer tissue, Mucin2 expression was increased. An increased signature of L1/Mucin2 expression reduced the survival rate of human colon cancer patients. Thus, induction of Mucin2 expression by L1 is required during mucinous colon cancer progression and can serve as a marker for diagnosis and a target for therapy.
Authors with CRIS profile
Thomas Brabletz
Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung
Involved external institutions
Israel (IL)How to cite
APA:
Saha, A., Gavert, N., Brabletz, T., & Ben-Ze’ev, A. (2023). An Increase in Mucin2 Expression Is Required for Colon Cancer Progression Mediated by L1. International Journal of Molecular Sciences, 24(17). https://doi.org/10.3390/ijms241713418
MLA:
Saha, Arka, et al. "An Increase in Mucin2 Expression Is Required for Colon Cancer Progression Mediated by L1." International Journal of Molecular Sciences 24.17 (2023).
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