Expression differences of programmed death ligand 1 in de-novo and recurrent glioblastoma multiforme
Heynckes S, Gaebelein A, Haaker G, Grauvogel J, Franco P, Mader I, Carro MS, Prinz M, Delev D, Schnell O, Heiland DH (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 8
Pages Range: 74170-74177
Journal Issue: 43
DOI: 10.18632/oncotarget.18819
Abstract
The biology of recurrent glioblastoma multiforme (GBM) is a dynamic process influenced by selection pressure induced by different antitumoural therapies. The poor clinical outcome of tumours in the recurrent stage necessitates the development of effective therapeutic strategies. Checkpoint-inhibition (PD1/PD-L1 Inhibition) is a hallmark of immunotherapy being investigated in ongoing clinical trials. The purpose of this study was to analyse the PD-L1 expression in de-novo and recurrent glioblastoma multiforme and to explore associated genetic alterations and clinical traits. We show that PD-L1 expression was reduced in recurrent GBM in comparison to de-novo GBM. Additionally, patients who received an extended dose of temozolomide (TMZ) chemotherapy showed a significantly reduced level of PD-L1 expression in the recurrence stage compared to the corresponding de-novo tumour. Our findings may provide an explanation for potentially lower response to immunotherapy in the recurrent stage due to the reduced expression of the therapeutic target PD-L1.
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Germany (DE)How to cite
APA:
Heynckes, S., Gaebelein, A., Haaker, G., Grauvogel, J., Franco, P., Mader, I.,... Heiland, D.H. (2017). Expression differences of programmed death ligand 1 in de-novo and recurrent glioblastoma multiforme. Oncotarget, 8(43), 74170-74177. https://doi.org/10.18632/oncotarget.18819
MLA:
Heynckes, Sabrina, et al. "Expression differences of programmed death ligand 1 in de-novo and recurrent glioblastoma multiforme." Oncotarget 8.43 (2017): 74170-74177.
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