CD40/CD154 system and pro-inflammatory cytokines in young healthy male smokers without additional risk factors for atherosclerosis
Garlichs C, Cicha I, Raaz-Schrauder D, Meyer L, Stumpf C, Klinghammer L, Yilmaz A, Daniel W (2009)
Publication Type: Journal article
Publication year: 2009
Journal
Book Volume: 58
Pages Range: 306-311
Journal Issue: 6
DOI: 10.1007/s00011-008-8084-8
Abstract
Objective and design:: Atherosclerosis, as an inflammatory disease, is characterized by pathologically altered levels of cytokines. We investigated whether smoking affects the CD40/CD154 system and pro-inflammatory cytokines in young males without other risk factors for atherosclerosis. Subjects:: Young male smokers (n=13) and 14 non-smoking controls were investigated. Methods:: The differences in CD40/CD154 system and serum cytokines between the groups were measured using flow cytometry and ELISA. Results:: In smokers, there was a strong trend (P<0.06) for increased CD40 expression on platelets as compared with non-smokers. However, there were no significant differences in CD40 expression on monocytes or in CD154 expression on platelets and T-cells between smokers and non-smokers. There was a strong trend for increased platelet-monocyte aggregates in smokers (P<0.06). Also, smokers had slightly but not significantly elevated hsCRP and IL-6 levels, and slightly decreased TNF-α and MCP-1. Interestingly, IL-18, a cytokine which has the ability to promote both Th1 and Th2 responses, was significantly decreased in smokers group (P=0.03 vs controls). Conclusions:: In young healthy males, smoking is not associated with dramatic changes in CD40/CD154 system. However, cigarette smoke alters the secreted cytokine profile, leading to significant decrease in systemic IL-18 levels. © 2009 Birkhäuser Verlag, Basel.
Authors with CRIS profile
Christoph Garlichs
Medizinische Fakultät
Iwona Cicha
Medizinische Fakultät
Dorette Raaz-Schrauder
Medizinische Fakultät
Christian Stumpf
Medizinische Fakultät
Lutz Klinghammer
Department of Medicine 2 – Cardiology and Angiology
Werner Daniel
Lehrstuhl für Innere Medizin II
Involved external institutions
Germany (DE)How to cite
APA:
Garlichs, C., Cicha, I., Raaz-Schrauder, D., Meyer, L., Stumpf, C., Klinghammer, L.,... Daniel, W. (2009). CD40/CD154 system and pro-inflammatory cytokines in young healthy male smokers without additional risk factors for atherosclerosis. Inflammation Research, 58(6), 306-311. https://doi.org/10.1007/s00011-008-8084-8
MLA:
Garlichs, Christoph, et al. "CD40/CD154 system and pro-inflammatory cytokines in young healthy male smokers without additional risk factors for atherosclerosis." Inflammation Research 58.6 (2009): 306-311.
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