Koch E, Steeb T, Bender-Säbelkampf S, Busch D, Feustel J, Kaufmann M, Maronna A, Meder C, Ronicke M, Toussaint F, Wellein H, Berking C, Heppt M (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 12
Article Number: 3813
Journal Issue: 11
DOI: 10.3390/jcm12113813
Background: Many treatments for actinic keratosis (AK) have been proven efficient in clinical trials. However, patients with AK may still experience unsatisfactory therapeutic outcomes in clinical practice. Objectives: To investigate patient adherence to self-applied topical interventions for AK and to explore factors associated with adherence in a real-world setting. Methods: A cross-sectional study was conducted. Patients presenting with AK were asked to complete a self-administered questionnaire about their last topical AK treatment. Results: A total of 113 patients participated with a median age of 78.5 years (range 58–94). Fifty-four patients (47.8%) received topical diclofenac, ten (8.8%) imiquimod, nine (8%) 5-fluorouracil, nine (8%) 5-fluorouracil plus salicylic acid, and eight (7.1%) photodynamic therapy. The non-adherence rate was 46.9% (n = 53), and only 30.9% (n = 35) used the topical treatments according to the summary of product characteristics (SmPC). These subgroups were compared. Patients of the non-compliant group were significantly less informed about the application time of the specific topical intervention (p = 0.002) and adjusted the timeframe (p < 0.001) and application frequency of the therapy (p = 0.02) independently of their physician. Conversely, patients reporting a sufficient pre-treatment consultation (p = 0.019) generally complied with the SmPC compliance application. Conclusions: A thorough pre-treatment consultation can help to increase treatment adherence and ensure lesion clearance.
APA:
Koch, E., Steeb, T., Bender-Säbelkampf, S., Busch, D., Feustel, J., Kaufmann, M.,... Heppt, M. (2023). Poor Adherence to Self-Applied Topical Drug Treatment Is a Common Source of Low Lesion Clearance in Patients with Actinic Keratosis—A Cross-Sectional Study. Journal of Clinical Medicine, 12(11). https://doi.org/10.3390/jcm12113813
MLA:
Koch, Elias, et al. "Poor Adherence to Self-Applied Topical Drug Treatment Is a Common Source of Low Lesion Clearance in Patients with Actinic Keratosis—A Cross-Sectional Study." Journal of Clinical Medicine 12.11 (2023).
BibTeX: Download