Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma

Erlmeier M, Mikuteit M, Zschaebitz S, Autenrieth M, Weichert W, Hartmann A, Steffens S, Erlmeier F (2023)

Publication Type: Journal article

Publication year: 2023

Journal

BMC Urology BioMed Central

Book Volume: 23

Article Number: 90

Journal Issue: 1

DOI: 10.1186/s12894-023-01263-0

Abstract

Background: The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). Methods: Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry. Results: 81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF− compared to HGF+ tumors (95.0% versus 90.9%; p = 0.410). Conclusions: In chRCC HGF expression is not associated with parameters of aggressiveness or survival.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Franziska Erlmeier Institute of Pathology

Involved external institutions

München Klinik Bogenhausen DE Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Erlmeier, M., Mikuteit, M., Zschaebitz, S., Autenrieth, M., Weichert, W., Hartmann, A.,... Erlmeier, F. (2023). Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma. BMC Urology, 23(1). https://doi.org/10.1186/s12894-023-01263-0

MLA:

Erlmeier, Maximilian, et al. "Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma." BMC Urology 23.1 (2023).

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