Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice

Gil-Pulido J, Cochain C, Lippert MA, Schneider N, Butt E, Amezaga N, Zernecke A (2017)

Publication Type: Journal article

Publication year: 2017

Journal

PLoS ONE Public Library of Science

Book Volume: 12

Article Number: e0181947

Journal Issue: 8

DOI: 10.1371/journal.pone.0181947

Abstract

Atherosclerosis is the main underlying cause for cardiovascular events such as myocardial infarction and stroke and its development might be influenced by immune cells. Dendritic cells (DCs) bridge innate and adaptive immune responses by presenting antigens to T cells and releasing a variety of cytokines. Several subsets of DCs can be discriminated that engage specific transcriptional pathways for their development. Basic leucine zipper transcription factor ATF-like 3 (Batf3) is required for the development of classical CD8α+ and CD103+ DCs. By crossing mice deficient in Batf3 with atherosclerosis-prone low density lipoprotein receptor (Ldlr-/-)-deficient mice we here aimed to further address the contribution of Batf3-dependent CD8α+ and CD103+ antigen-presenting cells to atherosclerosis. We demonstrate that deficiency in Batf3 entailed mild effects on the immune response in the spleen but did not alter atherosclerotic lesion formation in the aorta or aortic root, nor affected plaque phenotype in low density lipoprotein receptor-deficient mice fed a high fat diet. We thus provide evidence that Batf3-dependent antigen-presenting cells do not have a prominent role in atherosclerosis.

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE)

How to cite

APA:

Gil-Pulido, J., Cochain, C., Lippert, M.A., Schneider, N., Butt, E., Amezaga, N., & Zernecke, A. (2017). Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice. PLoS ONE, 12(8). https://doi.org/10.1371/journal.pone.0181947

MLA:

Gil-Pulido, Jesus, et al. "Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice." PLoS ONE 12.8 (2017).

BibTeX: Download