Local amplifiers of IL-4Ra-mediated macrophage activation promote repair in lung and liver
Minutti CM, Jackson-Jones LH, Garcia-Fojeda B, Knipper JA, Sutherland TE, Logan N, Rinqvist E, Guillamat-Prats R, Ferenbach DA, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C, Allen JE (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 356
Pages Range: 1076-1080
Journal Issue: 6342
Abstract
The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated.We have discovered local tissue-specific amplifiers of type 2-mediated macrophage activation. In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection, but resulted in fibrosis after peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.
Involved external institutions
University of Edinburgh
United Kingdom (GB)
Universidad Carlos III de Madrid (UC3M)
Spain (ES)
Forschungszentrum Borstel - Leibniz-Zentrum für Medizin und Biowissenschaften / Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Germany (DE)
Pennsylvania State University (Penn State)
United States (USA) (US)
Universidad Complutense de Madrid (UCM)
Spain (ES)
United Kingdom (GB)
Universidad Carlos III de Madrid (UC3M)
Spain (ES)
Forschungszentrum Borstel - Leibniz-Zentrum für Medizin und Biowissenschaften / Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Germany (DE)
Pennsylvania State University (Penn State)
United States (USA) (US)
Universidad Complutense de Madrid (UCM)
Spain (ES)
How to cite
APA:
Minutti, C.M., Jackson-Jones, L.H., Garcia-Fojeda, B., Knipper, J.A., Sutherland, T.E., Logan, N.,... Allen, J.E. (2017). Local amplifiers of IL-4Ra-mediated macrophage activation promote repair in lung and liver. Science, 356(6342), 1076-1080. https://doi.org/10.1126/science.aaj2067
MLA:
Minutti, Carlos M., et al. "Local amplifiers of IL-4Ra-mediated macrophage activation promote repair in lung and liver." Science 356.6342 (2017): 1076-1080.
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