Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen
Brook B, Harbeson D, Ben-Othman R, Viemann D, Kollmann TR (2017)
Publication Type: Journal article, Review article
Publication year: 2017
Journal
Book Volume: 39
Pages Range: 615-625
Journal Issue: 6
DOI: 10.1007/s00281-017-0651-z
Abstract
The burden of newborn infectious disease has long been recognized as the highest across the entire human life span. The precise underlying cause is unfortunately still far from clear. A substantial body of data derived mostly from in vitro experimentation indicates “lower” host immune responses in early vs. adult life and is briefly summarized within this review. However, emerging data derived mostly from in vivo experimentation reveal that the newborn host also exhibits an exuberant immune and inflammatory response following infection when compared to the adult. In this context, it is important to emphasize that “infection” does not equate “infectious disease,” as for many infections it is the host response to the infection that causes disease. This simple insight readily arranges existing evidence into cause-effect relationships that explain much of the increase in clinical suffering from infection in early life. We here briefly summarize the evidence in support of this paradigm and highlight the important implications it has for efforts to ameliorate the suffering and dying from infection in early life.
Involved external institutions
University of British Columbia
Canada (CA)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Canada (CA)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
How to cite
APA:
Brook, B., Harbeson, D., Ben-Othman, R., Viemann, D., & Kollmann, T.R. (2017). Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen. Seminars in Immunopathology, 39(6), 615-625. https://doi.org/10.1007/s00281-017-0651-z
MLA:
Brook, Byron, et al. "Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen." Seminars in Immunopathology 39.6 (2017): 615-625.
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