Dagvadorj N, Deuretzbacher A, Weisenberger D, Baumeister E, Trebing J, Lang I, Koechel C, Kapp M, Kapp K, Beilhack A, Huenig T, Einsele H, Wajant H, Grigoleit GU (2017)
Publication Type: Journal article
Publication year: 2017
Book Volume: 66
Pages Range: 319-332
Journal Issue: 3
DOI: 10.1007/s00262-016-1938-y
Due to its immunogenicity and overexpression concomitant with leukemia progression, Wilms tumor protein 1 (WT1) is of particular interest for immunotherapy of AML relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT). So far, WT1-specific T-cell responses have mainly been induced by vaccination with peptides presented by certain HLA alleles. However, this approach is still not widely applicable in clinical practice due to common limitations of HLA restriction. Dendritic cell (DC) vaccines electroporated with mRNA encoding full-length protein have also been tested for generating WT1-derived peptides for presentation to T-cells. Alternatively, an efficient and broad WT1 peptide presentation could be elicited by triggering receptor-mediated protein endocytosis of DCs. Therefore, we developed antibody fusion proteins consisting of an antibody specific for the DEC205 endocytic receptor on human DCs and various fragments of WT1 as DC-targeting recombinant WT1 vaccines (anti-hDEC205-WT1). Of all anti-hDEC205-WT1 fusion proteins designed for overcoming insufficient expression, anti-hDEC205-WT1
APA:
Dagvadorj, N., Deuretzbacher, A., Weisenberger, D., Baumeister, E., Trebing, J., Lang, I.,... Grigoleit, G.U. (2017). Targeting of the WT191–138 fragment to human dendritic cells improves leukemia-specific T-cell responses providing an alternative approach to WT1-based vaccination. Cancer Immunology, Immunotherapy, 66(3), 319-332. https://doi.org/10.1007/s00262-016-1938-y
MLA:
Dagvadorj, Nergui, et al. "Targeting of the WT191–138 fragment to human dendritic cells improves leukemia-specific T-cell responses providing an alternative approach to WT1-based vaccination." Cancer Immunology, Immunotherapy 66.3 (2017): 319-332.
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