CD4+ T cell help in cancer immunology and immunotherapy
Borst J, Ahrends T, Babala N, Melief CJM, Kastenmueller W (2018)
Publication Type: Journal article, Review article
Publication year: 2018
Journal
Book Volume: 18
Pages Range: 635-647
Journal Issue: 10
DOI: 10.1038/s41577-018-0044-0
Abstract
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish efficient and durable antitumour immunity. During priming, help signals are relayed from CD4+ T cells to CD8+ T cells by specific dendritic cells to optimize the magnitude and quality of the CTL response. In this Review, we highlight the cellular dynamics and membrane receptors that mediate CD4+ T cell help and the molecular mechanisms of the enhanced antitumour activity of CTLs. We outline how deficient CD4+ T cell help reduces the response of CTLs and how maximizing CD4+ T cell help can improve outcomes in cancer immunotherapy strategies.
Involved external institutions
Netherlands Cancer Institute (NKI)
Netherlands (NL)
Leiden University
Netherlands (NL)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Netherlands (NL)
Leiden University
Netherlands (NL)
Julius-Maximilians-Universität Würzburg
Germany (DE)
How to cite
APA:
Borst, J., Ahrends, T., Babala, N., Melief, C.J.M., & Kastenmueller, W. (2018). CD4+ T cell help in cancer immunology and immunotherapy. Nature reviews. Immunology, 18(10), 635-647. https://doi.org/10.1038/s41577-018-0044-0
MLA:
Borst, Jannie, et al. "CD4+ T cell help in cancer immunology and immunotherapy." Nature reviews. Immunology 18.10 (2018): 635-647.
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