Infarct growth precedes cerebral thrombosis following experimental stroke in mice
Gob V, Voll MG, Zimmermann L, Hemmen K, Stoll G, Nieswandt B, Schuhmann MK, Heinze KG, Stegner D (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 11
Article Number: 22887
Journal Issue: 1
DOI: 10.1038/s41598-021-02360-6
Abstract
Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, successful recanalization of occluded vessels is the primary therapeutic aim, but even if it is achieved, not all patients benefit. Although blockade of platelet aggregation did not prevent infarct progression, cerebral thrombosis as cause of secondary infarct growth has remained a matter of debate. As cerebral thrombi are frequently observed after experimental stroke, a thrombus-induced impairment of the brain microcirculation is considered to contribute to tissue damage. Here, we combine the model of transient middle cerebral artery occlusion (tMCAO) with light sheet fluorescence microscopy and immunohistochemistry of brain slices to investigate the kinetics of thrombus formation and infarct progression. Our data reveal that tissue damage already peaks after 8 h of reperfusion following 60 min MCAO, while cerebral thrombi are only observed at later time points. Thus, cerebral thrombosis is not causative for secondary infarct growth during ischemic stroke.
Involved external institutions
Germany (DE)How to cite
APA:
Gob, V., Voll, M.G., Zimmermann, L., Hemmen, K., Stoll, G., Nieswandt, B.,... Stegner, D. (2021). Infarct growth precedes cerebral thrombosis following experimental stroke in mice. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-02360-6
MLA:
Gob, Vanessa, et al. "Infarct growth precedes cerebral thrombosis following experimental stroke in mice." Scientific Reports 11.1 (2021).
BibTeX: Download