MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression

Heppt MV, Wang JX, Hristova DM, Wei Z, Li L, Evans B, Beqiri M, Zaman S, Zhang J, Irmler M, Berking C, Besch R, Beckers J, Rauscher FJ, Sturm RA, Fisher DE, Herlyn M, Fukunaga-Kalabis M (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Journal of Investigative Dermatology Elsevier

Book Volume: 138

Pages Range: 141-149

Journal Issue: 1

DOI: 10.1016/j.jid.2017.05.038

Abstract

Melanoma cells share many biological properties with neural crest stem cells. Here we show that the homeodomain transcription factor MSX1, which is significantly correlated with melanoma disease progression, reprograms melanocytes and melanoma cells toward a neural crest precursor-like state. MSX1-reprogrammed normal human melanocytes express the neural crest marker p75 and become multipotent. MSX1 induces a phenotypic switch in melanoma, which is characterized by an oncogenic transition from an E-cadherin–high nonmigratory state toward a ZEB1-high invasive state. ZEB1 up-regulation is responsible for the MSX1-induced migratory phenotype in melanoma cells. Depletion of MSX1 significantly inhibits melanoma metastasis in vivo. These results show that neural crest-like reprogramming achieved by a single factor is a critical process for melanoma progression.

Authors with CRIS profile

Carola Berking

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Wistar Institute US United States (USA) (US) University of Queensland AU Australia (AU) Massachusetts General Hospital US United States (USA) (US) New Jersey Institute of Technology (NJIT) US United States (USA) (US)

How to cite

APA:

Heppt, M.V., Wang, J.X., Hristova, D.M., Wei, Z., Li, L., Evans, B.,... Fukunaga-Kalabis, M. (2018). MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression. Journal of Investigative Dermatology, 138(1), 141-149. https://doi.org/10.1016/j.jid.2017.05.038

MLA:

Heppt, Markus V., et al. "MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression." Journal of Investigative Dermatology 138.1 (2018): 141-149.

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