Successful treatment of genital warts with ingenol mebutate monitored with optical coherence tomography and reflectance confocal microscopy

Reinholz M, Clanner-Engelshofen BM, Heppt M, Hirai Y, Ruzicka T, Berking C, Von Braunmuehl T (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Annals of Dermatology Korean Dermatological Association

Book Volume: 31

Pages Range: 434-437

Journal Issue: 4

DOI: 10.5021/ad.2019.31.4.434

Abstract

Ingenol mebutate (IM) is approved for the treatment of actinic keratosis and induces cell death in precancerous lesions. The efficacy of IM in the treatment of genital warts was investigated in a therapy-refractory patient. The 74-year-old male was treated with IM gel for three consecutive days. Treatment course and efficacy were evaluated by clinical inspection and non-invasive diagnostics namely optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). Within 24 to 48 hours IM induced a strong local inflammatory reaction. One week later a complete response was observed. OCT and RCM showed a strong reaction after treatment with erosions, swelling of cells, and a subepidermal dark band in representative lesions. IM has the advantage of a short treatment period in contrast to other topical treatments and shows a promising clinical outcome. Larger studies are needed to validate the data.

Authors with CRIS profile

Carola Berking

Involved external institutions

Klinikum der Universität München (Großhadern und Innenstadt) DE Germany (DE) Okayama University / 岡山大学 JP Japan (JP)

How to cite

APA:

Reinholz, M., Clanner-Engelshofen, B.M., Heppt, M., Hirai, Y., Ruzicka, T., Berking, C., & Von Braunmuehl, T. (2019). Successful treatment of genital warts with ingenol mebutate monitored with optical coherence tomography and reflectance confocal microscopy. Annals of Dermatology, 31(4), 434-437. https://doi.org/10.5021/ad.2019.31.4.434

MLA:

Reinholz, Markus, et al. "Successful treatment of genital warts with ingenol mebutate monitored with optical coherence tomography and reflectance confocal microscopy." Annals of Dermatology 31.4 (2019): 434-437.

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