A zinc selective oxytocin based biosensor

Mervinetsky E, Alshanski I, Tadi KK, Dianat A, Buchwald J, Gutierrez R, Cuniberti G, Hurevich M, Yitzchaik S (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Journal of Materials Chemistry B Royal Society of Chemistry

Book Volume: 8

Pages Range: 155-160

Journal Issue: 1

DOI: 10.1039/c9tb01932d

Abstract

Oxytocin is a peptide hormone with high affinity to both Zn2+ and Cu2+ ions compared to other metal ions. This affinity makes oxytocin an attractive recognition layer for monitoring the levels of these essential ions in biofluids. Native oxytocin cannot differentiate between Cu2+ and Zn2+ ions and hence it is not useful for sensing Zn2+ in the presence of Cu2+. We elucidated the effect of the terminal amine group of oxytocin on the affinity toward Cu2+ using theoretical calculations. We designed a new Zn2+ selective oxytocin-based biosensor that utilizes the terminal amine for surface anchoring, also preventing the response to Cu2+. The biosensor shows exceptional selectivity and very high sensitivity to Zn2+ in impedimetric biosensing. This study shows for the first time an oxytocin derived sensor that can be used directly for sensing Zn2+ in the presence of Cu2+

Involved external institutions

Hebrew University of Jerusalem IL Israel (IL) Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Mervinetsky, E., Alshanski, I., Tadi, K.K., Dianat, A., Buchwald, J., Gutierrez, R.,... Yitzchaik, S. (2019). A zinc selective oxytocin based biosensor. Journal of Materials Chemistry B, 8(1), 155-160. https://doi.org/10.1039/c9tb01932d

MLA:

Mervinetsky, Evgeniy, et al. "A zinc selective oxytocin based biosensor." Journal of Materials Chemistry B 8.1 (2019): 155-160.

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