Gold nanoprisms as optoacoustic signal nanoamplifiers for in vivo bioimaging of gastrointestinal cancers

Bao C, Beziere N, Del Pino P, Pelaz B, Estrada G, Tian F, Ntziachristos V, De La Fuente JM, Cui D (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Small Wiley-VCH Verlag

Book Volume: 9

Pages Range: 68-74

Journal Issue: 1

DOI: 10.1002/smll.201201779

Abstract

Early detection of cancer greatly increases the chances of a simpler and more effective treatment. Traditional imaging techniques are often limited by shallow penetration, low sensitivity, low specificity, poor spatial resolution or the use of ionizing radiation. Hybrid modalities, like optoacoustic imaging, an emerging molecular imaging modality, contribute to improving most of these limitations. However, this imaging method is hindered by relatively low signal contrast. Here, gold nanoprisms (AuNPrs) are used as signal amplifiers in multispectral optoacoustic tomography (MSOT) to visualize gastrointestinal cancer. PEGylated AuNPrs are successfully internalized by HT-29 gastrointestinal cancer cells in vitro. Moreover, the particles show good biocompatibility and exhibit a surface plasmon band centered at 830 nm, a suitable wavelength for optoacoustic imaging purposes. These findings extend well to an in vivo setting, in which mice are injected with PEGylated AuNPrs in order to visualize tumor angiogenesis in gastrointestinal cancer cells. Overall, both our in vitro and in vivo results show that PEGylated AuNPrs have the capacity to penetrate tumors and provide a high-resolution signal amplifier for optoacoustic imaging. The combination of PEGylated AuNPrs and MSOT represents a significant advance for the in vivo imaging of cancers. After excitation by light, a photoabsorber can emit ultrasound waves, which are in turn detected by a sound transducer. In this study, selected colon cancer HT-29 cells are research targets. PEGylated gold nanoprisms are designed and prepared with the aim to study the feasibility of using them as a novel contrast agent for the hybrid technique of optoacoustic imaging. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Involved external institutions

Shanghai Jiao Tong University / 上海交通大学 CN China (CN) Technische Universität München (TUM) DE Germany (DE) Universidad de Zaragoza ES Spain (ES) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE)

How to cite

APA:

Bao, C., Beziere, N., Del Pino, P., Pelaz, B., Estrada, G., Tian, F.,... Cui, D. (2013). Gold nanoprisms as optoacoustic signal nanoamplifiers for in vivo bioimaging of gastrointestinal cancers. Small, 9(1), 68-74. https://doi.org/10.1002/smll.201201779

MLA:

Bao, Chenchen, et al. "Gold nanoprisms as optoacoustic signal nanoamplifiers for in vivo bioimaging of gastrointestinal cancers." Small 9.1 (2013): 68-74.

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