Magnetic resonance myocardial perfusion imaging at 3.0 Tesla for the identification of myocardial ischaemia: comparison with coronary catheter angiography and fractional flow reserve measurements.
Ebersberger U, Makowski MR, Schoepf UJ, Platz U, Schmidtler F, Rose J, Kessel A, Roth P, Antoni D, Schnackenburg B, Helmberger T, Rieber J, Hoffmann E, Leber AW (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Book Volume: 14
Pages Range: 1174-1180
Journal Issue: 12
DOI: 10.1093/ehjci/jet074
Abstract
To assess image quality and diagnostic performance of 3.0 Tesla (3T) cardiac magnetic resonance (CMR) myocardial perfusion imaging with a dual radiofrequency source to detect functional relevant coronary artery disease (CAD), using coronary angiography and invasive pressure-derived fractional flow reserve (FFR) as reference standard. We included 116 patients with suspected or known CAD, who underwent 3T adenosine myocardial perfusion CMR (resolution 2.97 × 2.97 mm) and coronary angiography plus FFR measurements in intermediate lesions. Image quality of myocardial perfusion CMR was graded on a 4-point scale (1 = poor to 4 = excellent). Diagnostic accuracy was assessed by ROC analyses using a 16-myocardial segment-based summed perfusion score (0 = normal to 3 = transmural perfusion defect) and by determining sensitivity, specificity, positive and negative predictive value on the coronary vessel territory and the patient level. Diagnostic image quality was achieved for all stress myocardial perfusion CMR studies with an average quality score of 2.5, 3.1, and 3.0 for LAD, LCX, and RCA territories. The ability of the myocardial perfusion CMR perfusion score to detect significant coronary artery stenosis yielded an area under the curve of 0.93 on ROC analysis. Values for sensitivity, specificity, positive and negative predictive value on a vessel territory level and the patient level were 89, 95, 87, 96% and 85, 87, 77, 92%, respectively. In patients with suspected or known significant CAD, 3T myocardial perfusion CMR with standard perfusion protocols provides consistently high image quality and an excellent diagnostic performance.
Involved external institutions
Deutsches Herzzentrum München
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Medical University of South Carolina (MUSC)
United States (USA) (US)
München Klinik Bogenhausen
Germany (DE)
Philips Deutschland GmbH
Germany (DE)
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Medical University of South Carolina (MUSC)
United States (USA) (US)
München Klinik Bogenhausen
Germany (DE)
Philips Deutschland GmbH
Germany (DE)
How to cite
APA:
Ebersberger, U., Makowski, M.R., Schoepf, U.J., Platz, U., Schmidtler, F., Rose, J.,... Leber, A.W. (2013). Magnetic resonance myocardial perfusion imaging at 3.0 Tesla for the identification of myocardial ischaemia: comparison with coronary catheter angiography and fractional flow reserve measurements. European Heart Journal - Cardiovascular Imaging, 14(12), 1174-1180. https://doi.org/10.1093/ehjci/jet074
MLA:
Ebersberger, Ullrich, et al. "Magnetic resonance myocardial perfusion imaging at 3.0 Tesla for the identification of myocardial ischaemia: comparison with coronary catheter angiography and fractional flow reserve measurements." European Heart Journal - Cardiovascular Imaging 14.12 (2013): 1174-1180.
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