Embryonic heart progenitors and cardiogenesis

Brade T, Pane LS, Moretti A, Chien KR, Laugwitz KL (2013)

Publication Type: Journal article, Review article

Publication year: 2013

Journal

Cold Spring Harbor Perspectives in Medicine Cold Spring Harbor Laboratory Press

Book Volume: 3

Article Number: a013847

Journal Issue: 10

DOI: 10.1101/cshperspect.a013847

Abstract

The mammalian heart is a highly specialized organ, comprised of many different cell types arising from distinct embryonic progenitor populations during cardiogenesis. Three precursor populations have been identified to contribute to different myocytic and nonmyocytic cell lineages of the heart: cardiogenic mesoderm cells (CMC), the proepicardium (PE), and cardiac neural crest cells (CNCCs). This review will focus on molecular cues necessary for proper induction, expansion, and lineage-specific differentiation of these progenitor populations during cardiac development in vivo. Moreover, we will briefly discuss how the knowledge gained on embryonic heart progenitor biology can be used to develop novel therapeutic strategies for the management of congenital heart disease as well as for improvement of cardiac function in ischemic heart disease. © 2013 Cold Spring Harbor Laboratory Press; all rights reserved.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Karolinska Institute SE Sweden (SE)

How to cite

APA:

Brade, T., Pane, L.S., Moretti, A., Chien, K.R., & Laugwitz, K.-L. (2013). Embryonic heart progenitors and cardiogenesis. Cold Spring Harbor Perspectives in Medicine, 3(10). https://doi.org/10.1101/cshperspect.a013847

MLA:

Brade, Thomas, et al. "Embryonic heart progenitors and cardiogenesis." Cold Spring Harbor Perspectives in Medicine 3.10 (2013).

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