SiRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics

Taruttis A, Lozano N, Nunes A, Jasim DA, Beziere N, Herzog E, Kostarelos K, Ntziachristos V (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Nanoscale Royal Society of Chemistry

Book Volume: 6

Pages Range: 13451-13456

Journal Issue: 22

DOI: 10.1039/c4nr04164j

Abstract

Therapeutic applications of gene silencing using siRNA have seen increasing interest over the past decade. The optimization of the delivery and biodistribution of siRNA using liposome-gold nanorod (AuNRs) nanoscale carriers can greatly benefit from adept imaging methods that can visualize the time-resolved delivery performance of such vectors. In this work, we describe the effect of AuNR length incorporated with liposomes and show their complexation with siRNA as a novel gene delivery vehicle. We demonstrate the application of multispectral optoacoustic tomography (MSOT) to longitudinally visualize the localisation of siRNA carrying liposome-AuNR hybrids within tumors. Combination of in vivo MSOT with ex vivo fluorescence cryo-slice imaging offers further insight into the siRNA transport and activity obtained. This journal is

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) University of Manchester GB United Kingdom (GB) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE)

How to cite

APA:

Taruttis, A., Lozano, N., Nunes, A., Jasim, D.A., Beziere, N., Herzog, E.,... Ntziachristos, V. (2014). SiRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics. Nanoscale, 6(22), 13451-13456. https://doi.org/10.1039/c4nr04164j

MLA:

Taruttis, Adrian, et al. "SiRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics." Nanoscale 6.22 (2014): 13451-13456.

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