Radiotherapy in patients with vestibular schwannoma and neurofibromatosis type 2: Clinical results and review of the literature
Wagner J, Welzel T, Habermehl D, Debus J, Combs SE (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 100
Pages Range: 189-194
Journal Issue: 2
DOI: 10.1700/1491.16411
Abstract
Aims and background. To evaluate the long-term outcome of patients with vestibular schwannoma (VS) and neurofibromatosis type 2 (NF2) treated with fractionated stereotactic radiotherapy (FSRT) or stereotactic radiosurgery (SRS). Patients and methods. Sixteen VS in 14 patients with NF2 were treated with FSRT (n = 14) and SRS (n = 2). Patients with tumor progression and/or progression of clinical symptoms were selected for treatment. For patients treated with FSRT a median total dose of 57.6 Gy was prescribed with a median fractionation of 5 1.8 Gy per week. For patients who underwent SRS a median single dose of 17 Gy was prescribed to the 80% isodose. Results. FSRT and SRS were well tolerated. Local control rate was 94% for a median follow-up time of 131 months; 2- and 5-year progression-free survival were 100%. The probability of maintaining the pretreatment hearing level was 44%. Useful hearing preservation was 33%. Cranial nerve toxicity was moderate. Trigeminal nerve function worsened in 2 patients (12%) and facial nerve function in 3 patients (19%). One patient developed a new tinnitus. Conclusion. FSRT and SRS are both safe and effective noninvasive and minimally invasive treatment options for patients with VS in the setting of NF2. The long-term local control rates are excellent. Functional hearing preservation is worse in patients with VS and NF2 than in patients with sporadic VS. Copyright - Il Pensiero Scientifico Editore.
Involved external institutions
Germany (DE)How to cite
APA:
Wagner, J., Welzel, T., Habermehl, D., Debus, J., & Combs, S.E. (2014). Radiotherapy in patients with vestibular schwannoma and neurofibromatosis type 2: Clinical results and review of the literature. Tumori, 100(2), 189-194. https://doi.org/10.1700/1491.16411
MLA:
Wagner, Johanna, et al. "Radiotherapy in patients with vestibular schwannoma and neurofibromatosis type 2: Clinical results and review of the literature." Tumori 100.2 (2014): 189-194.
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