Implications of ultrasound frequency in optoacoustic mesoscopy of the skin
Schwarz M, Omar M, Buehler A, Aguirre J, Ntziachristos V (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 34
Pages Range: 672-677
Article Number: 6937184
Journal Issue: 2
Abstract
Raster-scan optoacoustic mesoscopy (RSOM) comes with high potential for in vivo diagnostic imaging in dermatology, since it allows for high resolution imaging of the natural chromophores melanin, and hemoglobin at depths of several millimeters. We have applied ultra-wideband RSOM, in the 10-160 MHz frequency band, to image healthy human skin at distinct locations. We analyzed the anatomical information contained at different frequency ranges of the optoacoustic (photoacoustic) signals in relation to resolving features of different skin layers in vivo. We further compared results obtained from glabrous and hairy skin and identify that frequencies above 60 MHz are necessary for revealing the epidermal thickness, a prerequisite for determining the invasion depth of melanoma in future studies. By imaging a benign nevus we show that the applied RSOM system provides strong contrast of melanin-rich structures. We further identify the spectral bands responsible for imaging the fine structures in the stratum corneum, assessing dermal papillae, and resolving microvascular structures in the horizontal plexus.
Involved external institutions
Germany (DE)How to cite
APA:
Schwarz, M., Omar, M., Buehler, A., Aguirre, J., & Ntziachristos, V. (2015). Implications of ultrasound frequency in optoacoustic mesoscopy of the skin. IEEE Transactions on Medical Imaging, 34(2), 672-677. https://doi.org/10.1109/TMI.2014.2365239
MLA:
Schwarz, Mathias, et al. "Implications of ultrasound frequency in optoacoustic mesoscopy of the skin." IEEE Transactions on Medical Imaging 34.2 (2015): 672-677.
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