Instantiated mixed effects modeling of Alzheimer's disease markers
Guerrero R, Schmidt-Richberg A, Ledig C, Tong T, Wolz R, Rueckert D (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 142
Pages Range: 113-125
DOI: 10.1016/j.neuroimage.2016.06.049
Abstract
The assessment and prediction of a subject's current and future risk of developing neurodegenerative diseases like Alzheimer's disease are of great interest in both the design of clinical trials as well as in clinical decision making. Exploring the longitudinal trajectory of markers related to neurodegeneration is an important task when selecting subjects for treatment in trials and the clinic, in the evaluation of early disease indicators and the monitoring of disease progression. Given that there is substantial intersubject variability, models that attempt to describe marker trajectories for a whole population will likely lack specificity for the representation of individual patients. Therefore, we argue here that individualized models provide a more accurate alternative that can be used for tasks such as population stratification and a subject-specific prognosis. In the work presented here, mixed effects modeling is used to derive global and individual marker trajectories for a training population. Test subject (new patient) specific models are then instantiated using a stratified “marker signature” that defines a subpopulation of similar cases within the training database. From this subpopulation, personalized models of the expected trajectory of several markers are subsequently estimated for unseen patients. These patient specific models of markers are shown to provide better predictions of time-to-conversion to Alzheimer's disease than population based models.
Involved external institutions
United Kingdom (GB)How to cite
APA:
Guerrero, R., Schmidt-Richberg, A., Ledig, C., Tong, T., Wolz, R., & Rueckert, D. (2016). Instantiated mixed effects modeling of Alzheimer's disease markers. NeuroImage, 142, 113-125. https://doi.org/10.1016/j.neuroimage.2016.06.049
MLA:
Guerrero, R., et al. "Instantiated mixed effects modeling of Alzheimer's disease markers." NeuroImage 142 (2016): 113-125.
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